Could vitamin d help stop bedwetting? new study tests the idea
NCT ID NCT06508333
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether giving children high-dose vitamin D pills along with a standard bedwetting alarm works better than the alarm alone. The trial included 262 children aged 5 to 18 who had low vitamin D levels and primary bedwetting. The main goal was to see if the combination reduced wet nights by at least half or stopped them completely.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Vitamin D3
- What this could lead to
- If it works, this could offer a simple, safe add-on treatment to help more children become dry at night.
- What could go wrong
- This is a completed trial, but the results are not yet published. The benefit may be small or not apply to all children with bedwetting.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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262 people
The number who actually took part.
- Started
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Dec 2024
- Finished
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May 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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5 to 18 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria * Children aged 5-18 years diagnosed with PMNE-defined as intermittent urinary incontinence during sleep in a children who are never dry for more than 6 months and have no other lower urinary tract symptoms-according to the latest International Children's Continence Society guidelines, presenting at outpatient urology clinics. * Serum vitamin D level below 30 ng/mL. * Written informed consent obtained from each participant and their guardian. * Adequate psychological and cognitive function, no communication barriers, and ability to accurately report symptoms and potential adverse reactions during treatment. Exclusion Criteria * Urological malformations or serious urological disease, such as hypospadias, cryptorchidism, posterior urethral valves, vesicoureteral reflux, neurogenic bladder, urinary tumors, urinary stones, or bladder/urethral injuries. * Neurological disorders, including epilepsy, spinal cord injury or dysplasia, spinal embolism syndrome, multiple sclerosis, autism spectrum disorder, or attention-deficit/hyperactivity disorder. * Endocrine diseases, such as diabetes mellitus or hyperthyroidism. * Severe systemic disease, including significant cardiac disease, renal or hepatic insufficiency, pulmonary disease, bone deformities, gastrointestinal disorders, or inherited metabolic disorders. * Conditions predisposing to sleep apnea, such as adenoid or tonsillar hypertrophy, deviated nasal septum, craniofacial abnormalities, or central sleep apnea. * History of gastrointestinal or urological surgery. * Use of anticonvulsant, antiepileptic, corticosteroid, or anti-tuberculosis medications. * History of hypercalcemia, hyperphosphatemia, or renal rickets. * Unexplained hematuria or urinary tract infection within the past year. * Allergy to vitamin D formulations. * Concurrent participation in other clinical studies. * Unwillingness to participate or poor anticipated follow-up compliance.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Children's Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, 400000, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.