Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Can vitamin c save burn victims? major trial halted midway

NCT ID NCT04138394

Disease control Sponsor: Clinical Evaluation Research Unit at Kingston General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused This study
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether giving high doses of vitamin C through an IV to severely burned patients could prevent organ failure and death. About 666 adults with deep burns covering at least 20% of their body were to receive either vitamin C or a placebo, alongside standard care. The trial was suspended, so we don't yet know if vitamin C helps.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
high-dose intravenous vitamin C (ascorbic acid)
What this could lead to
If it works, this could offer a simple, low-cost way to reduce organ damage and improve survival in severely burned patients.
What could go wrong
The trial is suspended, so results are unknown. High-dose vitamin C may cause side effects like kidney stones or interfere with other treatments. Early evidence is mixed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 666 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2020

Expected to finish

Mar 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 years of age or older * Deep 2nd and/or 3rd degree burns requiring skin grafting * Minimum burn size of ≥ 20% Total Body Surface Area (TBSA) Exclusion Criteria: * \>24 hours from admission to participating hospital to consent. * Patients admitted to burn unit \>24 from injury or accident. * Patients who are moribund (not expected to survive the next 72 hours). * Pregnancy (pregnancy will be ruled out as part of standard of care) or lactating. * Enrollment in another industry sponsored ICU intervention study. * Receiving high-dose IV vitamin C already (enteral or oral vitamin C is allowed). * Known glucose-6-phosphate dehydrogenase (G6PD) deficiency. * Recent history of kidney stones (within the last year). * Concomitant use of hydroxycobalamin (vitamin B12) for suspected cyanide poisoning.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Shock are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

burn Shock

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Shock Thermal burn

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    33 sites in 9 countries. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Arizona Burn Center Valleywise Health

    Phoenix, Arizona, 85008, United States

  • Ascension Columbia St. Mary's

    Milwaukee, Wisconsin, 53211, United States

  • BG Klinik Tübingen

    Tübingen, Baden-Wurttemberg, 72076, Germany

  • Belgium Military Hospital, Military Hospital

    Brussels, Belgium

  • Berufsgenossenschaftliche Unfallklinik Ludwigshafen

    Ludwigshafen, Germany

  • Bridgeport Hospital

    Bridgeport, Connecticut, 06610, United States

  • CHU de Québec-Université Laval, Hôpital de l'Enfant-Jésus

    Québec, Quebec, G1J 1Z4, Canada

  • Centre Hospitalier Universitaire de Liege

    Liège, Belgium

  • Centre de recherche du CHUM

    Montreal, Quebec, H2X 0A9, Canada

  • Centro Nacional del Quemado y Cirugías Reconstructivas

    Asunción, Paraguay

  • Chelsea and Westminster Hospital

    Chelsea, London, SW10 9NH, United Kingdom

  • Ghent University Hospital

    Ghent, Oost Vlaanderen, 9000, Belgium

  • Grand Hopital de Charleroi

    Charleroi, Hainaut, 6280, Belgium

  • Hamilton General Hospital, Hamilton Health Sciences Corporation

    Hamilton, Ontario, L8L 2X2, Canada

  • Harborview Medical Center - Seattle

    Seattle, Washington, 98104, United States

  • Hospital Central Dr. Ignacio Morones Prieto

    San Luis Potosí City, San Luis Potosí, 78290, Mexico

  • Hospital San Juan de Dios

    San José, Provincia de San José, Costa Rica

  • Klinikum St. George

    Leipzig, Saxony, 04129, Germany

  • MedStar Washington Hospital Center

    Washington D.C., District of Columbia, 20010, United States

  • Mercy Hospital St. Louis

    St Louis, Missouri, 63141, United States

  • Merheim Medical Center, Hospitals of Cologne

    Cologne, Germany

  • QEII Health Sciences Centre

    Halifax, Nova Scotia, B3H 3A6, Canada

  • Queen Elizabeth Hospital Birmingham

    Birmingham, Mindelsohn Way, B15 2TH, United Kingdom

  • RWTH Aachen University, Aachen

    Aachen, Germany

  • Siriraj Hospital, Mahidol University

    Bangkok, Bangkok, 10700, Thailand

  • St Helens and Knowsley Hospitals NHS Trust

    Prescot, L35 5DR, United Kingdom

  • Sunnybrook Health Sciences Centre, Ross Tilley Burn Centre

    Toronto, Ontario, M4N 3M5, Canada

  • The Mid Yorkshire Hospitals NHS Trust

    Wakefield, United Kingdom

  • The Ohio State University Medical Center

    Ohio City, Ohio, 43210, United States

  • The University of Chicago Medical Center

    Chicago, Illinois, 60637, United States

  • University Hospital Würzburg

    Würzburg, Germany

  • University of Iowa Hospitals & Clinics

    Iowa City, Iowa, 52242, United States

  • University of Texas Health Science Center - Houston

    Houston, Texas, 77030, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.