Gene-Editing shot aims to slash 'Bad' cholesterol for good
NCT ID NCT06164730
First seen Nov 17, 2025 · Last updated Jun 16, 2026 · Updated 34 times
Summary
This early-phase study tests a single dose of VERVE-102, a gene-editing therapy, in 85 adults with inherited high cholesterol (HeFH) or early heart disease who still need lower LDL cholesterol. The treatment targets a liver gene (PCSK9) to reduce 'bad' cholesterol levels. The main goal is to check safety, but researchers will also measure how well it lowers cholesterol.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Clinical Study Center
RECRUITINGDothan, Alabama, 36305, United States
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Clinical Study Center
RECRUITINGPomona, California, 91768, United States
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Clinical Study Center
RECRUITINGBoca Raton, Florida, 33434, United States
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Clinical Study Center
RECRUITINGJacksonville, Florida, 32216, United States
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Clinical Study Center
RECRUITINGWinter Park, Florida, 32789, United States
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Clinical Study Center
RECRUITINGHigh Point, North Carolina, 27260, United States
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Clinical Study Center
RECRUITINGDeSoto, Texas, 75115, United States
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Clinical Study Center
RECRUITINGRenton, Washington, 98057, United States
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Clinical Study Center
RECRUITINGAdelaide, Australia
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Clinical Study Center
RECRUITINGMelbourne, Australia
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Clinical Study Center
RECRUITINGSydney, Australia
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Clinical Study Center
RECRUITINGChicoutimi, Canada
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Clinical Study Center
RECRUITINGMontreal, Canada
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Clinical Study Center
RECRUITINGQuébec, Canada
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Clinical Study Center
RECRUITINGToronto, Canada
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Clinical Study Center
RECRUITINGVancouver, Canada
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Clinical Study Center
RECRUITINGRehovot, Israel
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Clinical Study Center
RECRUITINGChristchurch, New Zealand
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Clinical Study Center
RECRUITINGBirmingham, United Kingdom
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Clinical Study Center
RECRUITINGEdinburgh, United Kingdom
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Clinical Study Center
RECRUITINGLondon, United Kingdom
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Clinical Study Center
RECRUITINGManchester, United Kingdom
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Clinical Study Center
RECRUITINGNottingham, United Kingdom
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.