Which ventilator keeps oxygen levels steadier during hospital transport?
NCT ID NCT07198269
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two types of ventilators (breathing machines) used when moving patients who are on life support within or between hospitals. The goal is to see if a new ventilator (TV80) keeps oxygen levels as stable as a standard one (HAMILTON-T1). About 98 adults will be randomly assigned to one ventilator or the other, and their oxygen levels and vital signs will be measured before and after transport.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 98 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Dec 2025
An estimate. Start dates often move.
- Expected to finish
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Jun 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Aged ≥ 18 years and \< 80 years. * Patients receiving invasive mechanical ventilation. * Patients requiring intra-hospital transport or inter-hospital transfer. * Patients whose legal representatives have provided written informed consent for participation in the trial. Exclusion Criteria: * Subjects with shock or hemodynamic instability that has not been treated * Subjects receiving high-dose vasopressor support (equivalent norepinephrine dose \> 1µg/kg/min) * Patients receiving ECMO support * Subjects with hemoglobin \< 6g/dL * Subjects with cardiac arrest without resuscitation treatment * Patients who are moribund or discharged due to deteriorating condition * Patients with bullae, pneumothorax without closed thoracic drainage, especially tension pneumothorax * Massive hemoptysis, and respiratory failure caused by massive hemoptysis or severe aspiration * Pregnant and lactating women * Patients with mental illness * Subjects whose legal representatives have not provided informed consent * Patients without access to trial ventilators during the trial, including when trial ventilators are in use or malfunctioning * Expected transport duration exceeding 1 hour or combined transport scenarios (helicopter combined with ambulance)
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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2 nd Affiliated Hospital, School of Medicine, Zhejiang University, China
Hangzhou, Zhejiang, 310009, China