Head-to-Head: which drug eases unexplained pain better?
NCT ID NCT06803485
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 39 times
Summary
This study compares two antidepressants, venlafaxine and dosulepin, to see which one better reduces pain and other physical symptoms in people with somatic symptom disorder. Researchers will enroll 84 adults who have not recently taken medication for this condition. The trial also looks at changes in stress hormones and inflammation markers to understand how these drugs work.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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All India Institute of Medical Sciences (AIIMS)
RECRUITINGBhubaneswar, Odisha, 751019, India
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
venlafaxine and dosulepin
What this could lead to
If this trial succeeds, it could point toward a more effective medication for managing pain and other physical symptoms in people with somatic symptom disorder.
What could go wrong
This is a small, early-phase trial with only 84 participants, so results may not apply to everyone. Both drugs have known side effects, and the study may not find a clear winner.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.