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Aging and thirst: new study probes why seniors are prone to dehydration

NCT ID NCT06930300

Knowledge-focused Sponsor: University Hospital, Basel, Switzerland Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how healthy older adults (60+) handle water balance compared to younger people (18-30). Researchers measured a hormone called copeptin, which is linked to vasopressin, after giving either salt water (to stimulate the hormone) or plain water (to suppress it). The goal was to see if age-related changes in this hormone explain why elderly people are more at risk for dehydration or overhydration. The study involved 32 participants and was completed at a university hospital in Switzerland.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

32 people

The number who actually took part.

Started

Apr 2025

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-30 years or ≥ 60 years * Normonatremia (135-145 mmol/L) * Plasma osmolality 280-300 mOsm/kg * BMI ≥18 and ≤ 30 kg/m2 Exclusion Criteria: * Regular use of medication with effects on water homeostasis (e.g. blood pressure medication, neuroleptics, desmopressin, etc.) * Any severe disease requiring frequent medical care, except physiotherapy and/or psychotherapy * Pacemaker or ICD * History of thrombosis * Active oncologic disease * Heart failure * Liver cirrhosis * Estimated glomerular filtration rate (eGFR) \< 60 ml/kg/1.73 m2 * Uncontrolled hypertension \>160 mmHg systolic or \>100 mmHg diastolic * Polydipsia (ingestion of \>3L fluids per day) and polyuria (\>50 ml/kg urine production within 24 hours) * Pregnancy or breastfeeding * Participation in a study with investigational drugs within 30 days * Acute illness * Inability to follow study procedures

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy ageing

Contacts and locations

Locations

  • University Hospital Basel

    Basel, Canton of Basel-City, 4031, Switzerland

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