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Could a sprinkle of antibiotic powder in joint surgery stop infections?

NCT ID NCT04399642

Prevention Sponsor: Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looks at whether putting vancomycin powder directly into the joint during hip or knee replacement surgery can prevent infections better than standard IV antibiotics alone. About 1,800 adults having primary or revision joint replacement are being followed for two years. The goal is to see if the extra powder reduces infection rates after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
vancomycin powder
What this could lead to
If it works, this could provide a simple, low-cost way to reduce infections after joint replacement surgery, potentially improving recovery and reducing complications.
What could go wrong
This is a single study with results not yet reported. The added antibiotic may not lower infection rates and could carry risks like allergic reactions or antibiotic resistance.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 1,832 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2019

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Standard criteria for the implantation of primary total hip or knee replacement * Revision of an aseptic THA or TKA. * Adults \>18 years of age * Diagnosis of Osteoarthrosis (OA), Osteonecrosis (ON), Arthritis; or aseptic loosening of THA/TKA. * Subject is willing to consent to participate in the study * Subject is available for follow-up through at least 2 years * Subject has met acceptable preoperative medical clearance and is free of or treated for medical conditions that would pose excessive operative risk. * Subject who are fluent in English and / or French and able to understand their role in the study Exclusion Criteria: * Active, local infection or systemic infection. * Participation in any other pharmaceutical, biologic or medical device clinical investigation * Subjects with known allergy to vancomycin * Subjects unable to consent * Patient with skin pathology

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Conditions

The condition(s) this trial relates to.

arthritic joint disease Infections infectious disease osteoarthritis osteoarthritis susceptibility 1 osteonecrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Infection

Contacts and locations

Locations

  • Hopital Sacré-Coeur de Montreal

    Montreal, Quebec, H4J 1C5, Canada

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