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Could a 'Flora Transplant' stop recurring vaginal infections?

NCT ID NCT02236429

Disease control Sponsor: Hadassah Medical Organization Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether transferring healthy vaginal bacteria from donors can cure recurrent bacterial vaginosis (BV). Ten women with frequent BV will receive the transplant. The goal is to restore natural balance and prevent repeat infections without antibiotics.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
vaginal flora transplant
What this could lead to
If it works, this could offer a new way to treat recurrent bacterial vaginosis without relying on repeated antibiotics.
What could go wrong
This is a very small early trial with only 10 participants. It may not work for everyone, and there are risks of infection or rejection of the donor bacteria.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 10 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2015

Expected to finish

Mar 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * recurrent BV (4 or more incidences in the past year) * recurrence of BV in less than 2 months of antibiotic treatment or need for prophylactic antibiotic * 3/4 Amsel criteria and Nugent criteria greater or equal to 7 Exclusion Criteria: * pregnancy or planned pregnancy during the study period * other known diseases * carriers of Hep B and C * HIV or syphilis positive

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Conditions

The condition(s) this trial relates to.

bacterial vaginosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Recurrent bacterial vaginitis

Contacts and locations

Locations

  • Hadassah Medical Organization

    Jerusalem, Israel