Could your genes make labor harder? new study investigates
NCT ID NCT01107158
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether certain genetic variations (SNPs) in cholesterol-related genes (LXRs) are linked to difficult labor (dystocia) that requires a C-section. Researchers planned to analyze blood samples from 58 women having C-sections due to stalled labor. The study was terminated early, so findings are limited.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could help identify genetic markers that predict risk of difficult labor, potentially guiding future prevention or treatment strategies.
- What could go wrong
- This was a small pilot study that was terminated early, so results are limited. The link between these genes and labor problems is still unproven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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58 people
The number who actually took part.
- Start date
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Apr 2010
- Finished
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Sep 2015
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study population represents women undergoing a difficult, stagnating labor due to either physical or uterine dystocia.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients undergoing C-section for a dystocia: 2 to 3 hours of stagnation in labor progress are observed (ie no increasing dilation, and uterine contractions less that 3-5 per 10 minutes) in spite of measures taken to overcome dystocia (oxytocin injection and artificial breaking of waters) * the child is alive * the child does not have apriori known malformations that could interfere with a vaginal birth * foetus in cephalic position * full term pregnancy (\>= 37 weeks of amenorrhea) * single birth * patient has signed consent * patient is affiliated with a social security system Exclusion Criteria: * vaginal birth * programmed C-section * C-section is chosen because the fetus has a cardia rhythm problem, and there is no stagnation in the labor process * multiple pregnancy * the child is in a breech position * premature birth (\<37 weeks amenorrhea) * in utero fetal death * fetal malformation known before birth that could interfere with a vaginal birth * non french-speaking patient (impossible to correctly inform the patient) * patient under guardianship
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Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centre Hospitalier Universitaire de Nîmes
Nîmes, 30029, France