Simple test could unlock better monitoring for rare metabolic disorders
NCT ID NCT05671666
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing a new way to measure how well the urea cycle works in healthy people and in patients with urea cycle disorders (UCDs). Participants receive a safe, non-radioactive tracer, and blood samples are taken over a few hours. The goal is to develop a better tool for evaluating current and future treatments for UCDs.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- stable ammonium chloride isotope tracer
- What this could lead to
- If successful, this test could provide a better way to measure how well the urea cycle works, helping to evaluate new treatments for urea cycle disorders.
- What could go wrong
- This is an early diagnostic study, not a treatment trial. The test may not prove useful for all patients or may not be widely adopted.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Oct 2019
- Expected to finish
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Dec 2035
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * healthy subjects at any age and given written informed consent * subjects with a UCD confirmed by genetic or enzymatic diagnostics at any age and given written informed consent Exclusion Criteria: * healthy subjects with acute and chronic disease requiring treatment of any kind * pregnant or lactating women. * UCD patients with acute and chronic (other than her/his UCD) disease requiring treatment * UCD patients in which intake of carglumic acid cannot be stopped for 24 hours prior to the test
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University Children's Hospital
RECRUITINGZurich, Canton of Zurich, 8008, Switzerland
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