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Can light therapy boost eczema treatment? new trial tests UVB plus creams

NCT ID NCT05704205

Disease control Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding narrowband UVB phototherapy (a type of light treatment) to optimized topical therapy (creams, ointments, and skin care advice) helps adults with moderate atopic eczema more than topical therapy alone. About 316 adults whose eczema is not well controlled by standard creams will be randomly assigned to receive either UVB light three times a week for 8-16 weeks plus topical care, or topical care only. The main goal is to see how many achieve a 50% reduction in eczema severity after 3 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Narrowband UVB phototherapy (a type of light therapy) plus optimized topical therapy (creams, ointments, and lifestyle advice)
What this could lead to
If it works, this could show that adding UVB light therapy to standard creams helps more people with eczema get clearer skin than creams alone.
What could go wrong
This is a mid-stage trial, not yet proven in large populations. UVB therapy requires frequent clinic visits and may cause skin irritation or long-term skin damage. The benefit over topical therapy alone may be small.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 316 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2023

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult (≥18 years of age) patient meeting the UK working party criteria for atopic eczema; * AE insufficiently controlled by standard topical care and therefore eligible for NB-UVB or OTT; * Investigator Global Assessment (IGA, 0-4) of ≥ 2 (moderate disease); * Eczema Area and Severity Index (EASI) of ≥ 7 (moderate disease); * Understood and voluntarily signed and dated an informed consent form prior to any study-related procedure or has a legal representative who has, and is willing to comply with the study's requirements. Exclusion Criteria: * Contra-indication for NB-UVB; * Genetic defects associated with photosensitivity or skin cancer; * Heavily photo-damaged skin; * History of multiple (\>1) skin malignancies; * Use of systemic immunosuppressants/immunomodulators; * Use of medication associated with photosensitivity; * Patient is already on systemic AE therapy; * Patient is already on OTT in the past 2 months; * NB-UVB or any systemic therapy in the past 9 months.

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Conditions

The condition(s) this trial relates to.

atopic eczema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atopic dermatitis Atopic dermatitis (eczema)

Contacts and locations

Locations

  • Alrijne Ziekenhuis

    Leiderdorp, South Holland, Netherlands

  • Amsterdam Universitair Medische Centra

    Amsterdam, North Holland, 1105 AZ, Netherlands

  • Bergman Clinics

    Haarlem, North Holland, 2015 BJ, Netherlands

  • Centrum Oosterwal

    Alkmaar, North Holland, 1817 MS, Netherlands

  • Dijklander Ziekenhuis

    Purmerend, North Holland, 1441 RN, Netherlands

  • Erasmus Medisch Centrum

    Rotterdam, South Holland, 3015 GD, Netherlands

  • Flevoziekenhuis

    Almere Stad, Flevoland, 1315RA, Netherlands

  • Huid Medisch Centrum

    Amsterdam, North Holland, 1105 BJ, Netherlands

  • Isala Klinieken

    Zwolle, Overijssel, Netherlands

  • Jeroen Bosch Ziekenhuis

    's-Hertogenbosch, North Brabant, 5223 GZ, Netherlands

  • Leids Universitair Medisch Centrum

    Leiden, South Holland, 2333 ZA, Netherlands

  • Meander Medisch Centrum

    Amersfoort, Utrecht, 3813 TZ, Netherlands

  • Medisch Centrum Leeuwarden

    Leeuwarden, Provincie Friesland, 8934 AD, Netherlands

  • OLVG

    Amsterdam, North Holland, 1061 AE, Netherlands

  • Reinier de Graaf Gasthuis

    Delft, South Holland, 2625 AD, Netherlands

  • Spaarne Gasthuis

    Hoofddorp, North Holland, 2134 TM, Netherlands

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