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Massive study aims to decode mysteries of long ICU stays

NCT ID NCT07510776

Knowledge-focused Sponsor: Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at 7000 adult patients who stayed in the intensive care unit (ICU) for more than 5 days. The goal is to find different patterns among those who remain critically ill for a long time (over 10-14 days). By analyzing medical data, researchers hope to understand why some patients recover slowly and how to personalize their care for better outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 7,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This study will include adult patients (≥18 years old) who are consecutively admitted to participating intensive care units (ICUs) and remain in the ICU for 5 or more days. The focus will be on patients who survive the early phase of critical illness, allowing the formation of a relatively homogeneous cohort of early ICU survivors. The population will comprise patients with a wide range of critical illnesses, including sepsis, respiratory failure, cardiovascular instability, and multi-organ dysfunction, who require ongoing organ support such as invasive mechanical ventilation or vasopressors. Patients with prolonged ICU stays exceeding 10 days who continue to require organ support will be further characterized as having Persistent Critical Illness.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients aged 18 years or older; * ICU length of stay equal to or greater than 5 days. Exclusion Criteria: * Patients with an ICU stay \< 5 days; * Patients discharged from the ICU early due to lack of ward availability, rather than clinical recovery; * Patients who do not survive the early phase of critical illness (i.e., early ICU deaths).

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Conditions

The condition(s) this trial relates to.

Critical Illness

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Critical care Critical care medicine Critical care, intensive care Critical illness Recovery outcomes

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    7 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Centro Hospitalar de São João / ULS São João

    RECRUITING

    Lisbon, Lisbon District, Portugal

  • Hospital Garcia de Orta / ULS Almada-Seixal

    RECRUITING

    Lisbon, Lisbon District, Portugal

  • Hospital Prof. Doutor Fernando Fonseca / ULS Amadora -Sintra

    RECRUITING

    Lisbon, Lisbon District, Portugal

  • Hospital Santa Maria / ULS Santa Maria

    RECRUITING

    Lisbon, Lisbon District, Portugal

  • Hospital São Francisco Xavier / Centro Hospitalar de Lisboa Ocidental

    RECRUITING

    Lisbon, Lisbon District, Portugal

  • Hospital de VIla Nova de Gaia-Espinho / ULS Gaia e Espinho

    NOT_YET_RECRUITING

    Vila Nova de Gaia, Porto District, Portugal

  • Hospital de Vila Franca de Xira / ULS Estuário do Tejo

    RECRUITING

    Lisbon, Lisbon District, Portugal

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