Mpox study in guinea aims to unlock secrets of virus spread and vaccine power

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. MOVIE-West Africa * Individuals of any sex and age. * Confirmed Mpox cases who tested positive for MPXV by PCR. * Symptom onset within the 10 days prior to the baseline assessment. * Willingness and ability to comply with study procedures and attend scheduled follow-up visits for up to two months. * Availability for follow-up throughout the study period. * Provision of written informed consent by the participant, or consent by a legally authorized representative for minors or individuals unable to provide it themselves. * Assent obtained from children aged 12 to 17 years. * For individuals who cannot read or write, witnessed consent will be obtained. 2. TRACE-West Africa * Individuals who have had close physical contact with a PCR-confirmed Mpox case within 14 days from the onset of symptoms in the index case. * Close physical contact is defined as being within 2 meters of an infected person-particularly in enclosed spaces-for at least 5 minutes (based on CDC's 2-meter rule for droplet transmission). * Willingness and ability to comply with the study protocol and attend scheduled follow-up assessments. * Provision of written informed consent by the participant, or consent by a legally authorized representative for individuals unable to provide it themselves. * Assent obtained from children aged 12 to 17 years. * For individuals who cannot read or write, witnessed consent will be obtained. 3. VE-West Africa * The inclusion criteria for Mpox cases in VE-West Africa are same as those in MOVIE-West Africa. * The inclusion criteria for contacts of Mpox cases in VE-West Africa are as follows. * Individuals who have had close physical contact with a PCR-confirmed Mpox case within 14 days from the onset of symptoms in the index case. * Close physical contact is defined as being within 2 meters of an infected person-particularly in enclosed spaces-for at least 5 minutes (based on CDC's 2-meter rule for droplet transmission). * Individuals living, working or studying in a community where mpox vaccination is being offered. * Willingness and ability to comply with the study protocol and attend scheduled follow-up assessments. * Provision of written informed consent by the participant, or consent by a legally authorized representative for individuals unable to provide it themselves. * Assent obtained from children aged 12 to 17 years. * For individuals who cannot read or write, witnessed consent will be obtained. Exclusion Criteria: (1) MOVIE-West Africa * Cases of severe Mpox requiring hospitalization. * Individuals with a confirmed alternative diagnosis explaining their illness. (3) VE-West Africa * The exclusion criteria for Mpox cases in VE-West Africa are as follows. * Cases of severe Mpox requiring hospitalization. * Individuals with a confirmed alternative diagnosis explaining their illness.