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Iron clues could save lives in liver crisis

NCT ID NCT04807023

Knowledge-focused Sponsor: Rennes University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 98 adults with cirrhosis who were hospitalized for sudden worsening of their liver condition. Researchers measured different forms of iron in the blood to see how they relate to short-term death risk. The goal was to better understand iron's role in liver failure, which could lead to improved treatments in the future.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

98 people

The number who actually took part.

Started

Sep 2021

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patient with diagnosis of cirrhosis hospitalized for acute on chronic liver failure

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years old. * Diagnosis of cirrhosis, previously known or not, of any etiology, histologically proven or not. * Hospitalization for acute on chronic liver failure: * Ascites decompensation. * Or spontaneous infection of the ascites fluid (defined as PNN \> 250/mm3 of ascites). * Or digestive hemorrhage related to portal hypertension (digestive fibroscopy showing active bleeding or stigmas of recent bleeding from esophageal and/or gastric varices). * Or hepatic encephalopathy (clinically defined +/- increase in ammonia and/or by electroencephalogram and classified in stages according to West-Haven). * Or hepato-renal syndrome (HRS-AKI criteria, EASL 2018). * Or bacterial infection (defined by a bacteremia identified by at least one blood culture and/or an infectious site authenticated on imaging). * Or Acute Alcoholic Hepatitis (histologically proven or not). * Non-opposition of the patient, relative or legal representative. Exclusion Criteria: * Treatment with oral or intravenous iron in the month prior to hospitalization. * Implementation of a TIPS in the month prior to admission. * Presence of hepatocellular carcinoma with an expected survival \< 3 months or any other progressive cancer. * Adult person subject to legal protection (safeguard of justice, curatorship, guardianship), person deprived of liberty.

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Conditions

The condition(s) this trial relates to.

cirrhosis of liver Fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cirrhosis

Contacts and locations

Locations

  • CHU Rennes

    Rennes, France

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Other studies related to the condition(s) this trial covers.