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Sleep apnea breakthrough: tongue muscles key to breathing?

NCT ID NCT04322097

Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how specific tongue muscles help keep the airway open during sleep in people with obstructive sleep apnea. Researchers used a special camera during sleep-like sedation to measure airway collapse. The goal was to understand the mechanisms behind airway obstruction, which could lead to better treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could improve treatments for obstructive sleep apnea by targeting specific tongue muscles.
What could go wrong
This is an observational study, not a treatment trial. It may not lead to immediate clinical changes, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

133 people

The number who actually took part.

Started

Jun 2020

Finished

May 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

22 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Study A Inclusion Criteria: • Scheduled to undergo DISE as part of routine clinical standard of care. Study B Inclusion Criteria: * Adults (≥ 22yrs) willing and capable of providing informed consent * Implanted with the MRI-conditional Inspire hypoglossal nerve stimulator (Model 3028 or later) * Compliant with Inspire therapy (\> 20 hours/week over 2+ weeks) as a standalone treatment for sleep-disordered breathing * Inspire remote model 2500 or later. Study B Exclusion Criteria: * MRI contraindications (claustrophobia, ferromagnetic implants/foreign bodies, etc.) * Inspire Implant Model 3024 * Inspire Remote Model 3032 * Patients who have fallen asleep while during resulting in an accident or "near miss" accident within 1 year prior to device implantation. * Inability to sleep in the supine position (by self-report) * History of severe difficulty initiating or maintaining sleep in the laboratory * Pregnant women

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Conditions

The condition(s) this trial relates to.

obstructive sleep apnea syndrome Patient Compliance

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obstructive sleep apnea

Contacts and locations

Locations

  • Pennsylvania Hospital

    Philadelphia, Pennsylvania, 19107, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.