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Can running 100km change your Eye's blood vessels?

NCT ID NCT07748936

Knowledge-focused Sponsor: Centre Hospitalier Universitaire Dijon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This pilot study looks at whether running an ultra-trail race—a very long, intense endurance event—causes temporary changes in the tiny blood vessels at the back of the eye. Researchers will use a non-invasive imaging technique called OCT angiography to measure blood flow in the retina and choroid of ultra-trail runners before and shortly after the race. They will compare these measurements to a control group of active people who do not run the race. The goal is to understand how extreme physical exertion affects eye circulation and whether retinal imaging could serve as a window into overall cardiovascular health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Retinal imaging (OCT angiography and retinophotography) before and after an ultra-trail race
What this could lead to
If this works, it could show that simple eye scans can reveal how extreme exercise stresses the body's blood vessels, potentially aiding cardiovascular research and prevention.
What could go wrong
This is a small pilot study, so results may not apply broadly. Changes in eye blood flow after a race might be temporary and not reflect long-term health.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participant who has given free, informed, and verbal consent * Participant of legal age * Participant registered for the UTMA 100 km solo ultra-trail race (for the "ultra-trail" group) * Active subject not exposed to intense physical exertion (\>6 hours of exercise) within the 7 days prior to the enrollment visit (for the "active control" group) * Participant with an estimated physical activity level of 4-6 hours per week (for the "active control" group) * Participant agreeing to undergo ophthalmological examinations on the same schedule as the ultra-trail group (for the "active control" group) Exclusion Criteria: * Myopia \> 6 diopters * Type 1 or Type 2 diabetes * Protected individuals: Minors, individuals under legal protection (guardianship, conservatorship, court order), individuals unable to give informed consent * Individuals not enrolled in a social security program * Pregnant or breastfeeding women * Participants with a systemic or inflammatory vascular condition and cardiovascular risk * Participants with an ocular condition or ophthalmological history likely to impair retinal/choroidal microcirculation or the quality of imaging (vascular and degenerative macular conditions, cataracts) * Participants being treated with vasoconstrictors * Tobacco use within 4 hours prior to enrollment * Caffeine consumption within 1 hour prior to enrollment

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Choroidal microcirculation Oct angiography Physical exercion Retinal microcirculation

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Chu Dijon Bourgogne

    Dijon, 21000, France

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