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Which scope technique wins for tiny rectal tumors?

NCT ID NCT07759960

Disease control Sponsor: Nanfang Hospital, Southern Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This trial compares two minimally invasive endoscopic procedures—underwater endoscopic mucosal resection (UEMR) and endoscopic submucosal dissection (ESD)—for removing small rectal neuroendocrine tumors (NETs) that are 10 mm or smaller. The goal is to see if UEMR is as effective as ESD in completely removing the tumor in one piece, while also evaluating safety and procedure time. Adults aged 18 to 75 with suspected or confirmed small rectal NETs may participate. The findings could help doctors choose the best technique for this condition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Two endoscopic procedures: underwater endoscopic mucosal resection (UEMR) and endoscopic submucosal dissection (ESD)
What this could lead to
If one technique proves superior, it could become the preferred standard for removing small rectal neuroendocrine tumors, improving outcomes and reducing complications.
What could go wrong
This is a non-inferiority trial, so it may show the two methods are similar rather than one being better. Results may not apply to larger tumors or other patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 174 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age from 18 to 75 years; 2. With a high suspicion or evidence of rectal NET assessed using EUS, CT scan or colonoscopy; 3. With tumor size ≤10 mm assessed by colonoscopy or EUS; 4. Plan to receive UEMR or ESD treatment and provide written informed consent. Exclusion Criteria: 1. Unable to tolerate ESD or UEMR as assessed by the research team; 2. Complicated with serious diseases such as malignant tumor, which may lead to shorter life expectancy, the research team considers that it is not suitable for inclusion in the study after comprehensive evaluation; 3. Rectal NET with lymph node metastasis or distant metastasis; 4. Received resection of rectal neuroendocrine tumor by other surgical procedures; 5. Multiple rectal neuroendocrine tumors; 6. Vulnerable groups such as pregnant women or patients with mental disorders; 7. Poor compliance, unable to cooperate with treatment.

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Conditions

The condition(s) this trial relates to.

rectal neuroendocrine tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Rectal neuroendocrine tumor

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Nanfang Hospital, Southern Medical University

    RECRUITING

    Guangzhou, Guangdong, 510515, China