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Twins' 3D faces could reveal the real culprits behind aging

NCT ID NCT07760532

Knowledge-focused Sponsor: Ponsky Facial Aesthetics And Plastic Surgery, Llc Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This study uses identical twins to separate the effects of genetics from lifestyle and environment on facial aging. Researchers will take 3D images of each twin's face and compare them within pairs, looking at how factors like sun exposure, smoking, and use of GLP-1 weight-loss medications (like semaglutide) relate to differences in facial volume and wrinkles. No treatment is given; it's a single, 30-minute observation at a festival.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
GLP-1 receptor agonists (e.g., semaglutide, tirzepatide) observed via self-report; no medication is given.
What this could lead to
If it works, this could reveal how weight-loss drugs and lifestyle choices shape facial aging, helping people make informed decisions.
What could go wrong
This is an observational study, so it can't prove cause and effect. Results may be limited by self-reported data and the specific twin population.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult twin pairs attending the Twins Days Festival in Twinsburg, Ohio (August 8-9, 2026), the largest annual gathering of twins in the world. Participants are recruited on-site through a study booth and printed festival materials, and in advance through a study information page on the practice website. Anticipated enrollment is approximately 50 to 100 twin pairs (up to approximately 200 individual participants).

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years or older * Members of a monozygotic (identical) twin pair, with both twins present and willing to participate * Able to provide written informed consent in English Exclusion Criteria: * Age under 18 years * Inability or unwillingness to provide informed consent * Facial conditions or recent facial surgery that, in the investigator's judgment, would prevent standardized imaging * Pregnancy, by self-report Note: Zygosity is established by participant self-report, supported where available by prior DNA testing or physician confirmation. No genetic testing is performed and no biological specimens are collected. Pairs who self-report as dizygotic or are uncertain of their zygosity are recorded as such and analyzed separately from the confirmed monozygotic cohort.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Facial skin aging Facial volume loss Wrinkle appearance

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    1 site. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Ponsky Facial Aesthetics and Plastic Surgery, LLC

    Beachwood, Ohio, 44122, United States

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