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Nerve zaps plus hand training could boost stroke recovery

NCT ID NCT07272239

Symptom relief Sponsor: Riphah International University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a gentle nerve stimulation (tVNS) combined with hand therapy (mCIMT) can help people who had a stroke more than 6 months ago improve arm movement, thinking, and daily life. 50 adults with chronic stroke will be split into two groups: one gets both treatments plus standard rehab, the other gets only hand therapy plus standard rehab. The goal is to see if adding nerve stimulation leads to better recovery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

May 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Both male and female patients are included in the study. * Left sided ischemic stroke patients. * Patients with chronic, moderate-severe upper limb hemiparesis (\>6 months-2 years) * Stable participants having a stroke severity score \> 6 on National Institute of Health Stroke Scale (NIHSS). * Montreal Cognitive Assessment (MoCA) score ≥26. Exclusion Criteria: * Participants who show the symptoms of global or receptive aphasia. * Participants who have a history of significant neurological or psychiatric disorders, other than stroke, that could interfere with upper limb motor or sensory recovery. * Modified Ashworth scale score ≥ 3 of the affected upper extremity. * Patients who are not able to sit with or without support. * Patients with severe apraxia, somatosensory problems. * Resting heart rate (\< 50 beats/min). * Participants who are currently participating in another clinical trial or research study.

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Conditions

The condition(s) this trial relates to.

ischemic stroke stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cerebrovascular accident Stroke

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Al- firdous physiotherapy clinic

    RECRUITING

    Rawalpindi, Punjab Province, 46000, Pakistan

  • IIMCT- Railway General Hospital

    RECRUITING

    Rawalpindi, Punjab Province, 46000, Pakistan

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