Mini-Tumors in a dish could predict best cancer therapy
NCT ID NCT06612827
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing whether tiny lab-grown copies of a patient's tumor, called organoids, can help predict which cancer treatment will work best. Researchers will collect tumor and blood samples from 20 people with undifferentiated carcinoma before they start standard therapy. They will grow organoids from these samples and test different drugs on them, then compare the lab results with how the patient actually responds to treatment. The goal is to see if this method can guide personalized treatment decisions in the future.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- tumor organoid testing
- What this could lead to
- If successful, this approach could help doctors choose the most effective treatment for each patient with undifferentiated carcinoma, improving outcomes.
- What could go wrong
- This is a very small, early-stage study (20 participants) focused on feasibility. The organoid predictions may not match real patient responses, and results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 20 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2025
- Expected to finish
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Dec 2032
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patient with undifferentiated primary carcinoma (UPC) with indication for 1st-line treatment
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient with undifferentiated primary carcinoma (UPC) with histological and immunohistochemical evidence, validated in a local and/or national UPC multidisciplinary consultation * Patient with indication for systemic 1st-line treatment at the time of inclusion. Treatment may already have begun at the time of inclusion, but within the limit of 2 treatment cycles administered. * Patient with life expectancy greater than 3 months * Patient of legal age * Patient affiliated to a social security scheme * Signature of informed consent prior to any specific study procedure Exclusion Criteria: * Persons deprived of their liberty or under guardianship (including curatorship) * Pregnant or breast-feeding patient
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Centre François Baclesse
RECRUITINGCaen, France
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