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Kidney disease deep dive: 224 biopsies reveal new insights

NCT ID NCT06650111

Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked back at 224 patients with tubulointerstitial nephritis (TIN), a common cause of kidney failure. Researchers reviewed kidney biopsies to better understand the causes, treatments, and long-term outcomes of the disease. The goal is to improve how doctors diagnose and care for people with TIN.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

224 people

The number who actually took part.

Started

Mar 2025

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients with renal dysfunction whose main cause retained after etiological investigation is tubulointerstitial nephritis and treated at the Necker-Enfants Malades hospital or at the Georges Pompidou European hospital.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients who do not object to the use of their medical data and samples for this research * With a biopsy of the care on native kidney and subject to a biological collection, finding tubulointerstitial nephritis in the foreground and retained as the main cause of renal dysfunction after etiological investigation. * Signs of histological activity of the NTI objectified during the centralized rereading and defined by: * An inflammation of more than 10% of the surface of the entire cortical parenchyma (fibrous and non-fibrous) or a ti score \> or = 1 according to the Banff classification * AND/OR the presence of at least one granuloma on the biopsy Exclusion Criteria: * No access to medical records for data collection, or insufficient clinical data * Follow-up less than 3 months * Histological lesions of the tubulointerstitial sector but related to a hematological, urological, genetic etiology or the direct tubular toxicity of a drug

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Conditions

The condition(s) this trial relates to.

interstitial nephritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nephritis, interstitial

Contacts and locations

Locations

  • Hôpital Européen Georges Pompidou

    Paris, 75015, France

  • Hôpital Necker-Enfants Malades

    Paris, 75015, France

  • Hôpital Tenon

    Paris, 75020, France

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Other studies related to the condition(s) this trial covers.