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Hope for ataxia: new pill aims to slow worsening of balance and speech

NCT ID NCT03701399

First seen Nov 05, 2025 · Last updated May 24, 2026 · Updated 23 times

Summary

This study tests whether a daily pill called troriluzole can help adults with spinocerebellar ataxia, a rare brain disease that affects balance, walking, and speech. About 300 participants took either the drug or a placebo for 48 weeks. The main goal was to see if the drug slows down worsening of movement problems. This is a late-stage trial, but the drug is not a cure—it aims to control symptoms and slow disease progression.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Barrow Neurological Institute

    Phoenix, Arizona, 85013, United States

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • CNS Trials

    Long Beach, California, 90806, United States

  • Central South University Xiangya Hospital

    Changsha, Hunan, 410008, China

  • Columbia University

    New York, New York, 10032, United States

  • Duke University Movement Disorders Clinic

    Durham, North Carolina, 27705, United States

  • Emory

    Atlanta, Georgia, 30329, United States

  • Houston Methodist

    Houston, Texas, 77030, United States

  • Johns Hopkins Medicine

    Lutherville, Maryland, 21093, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic Florida

    Jacksonville, Florida, 32224, United States

  • Northwest Neurology, Ltd.

    Rolling Meadows, Illinois, 60008, United States

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • Swedish Health Services

    Seattle, Washington, 98122, United States

  • UCLA

    Los Angeles, California, 90095, United States

  • UCSF

    San Francisco, California, 94158, United States

  • University of Chicago

    Chicago, Illinois, 60637, United States

  • University of Colorado Hospital

    Aurora, Colorado, 80045, United States

  • University of Florida Health

    Gainesville, Florida, 32610, United States

  • University of Michigan

    Ann Arbor, Michigan, 48109, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19107, United States

  • University of South Florida

    Tampa, Florida, 33612, United States

  • West China Hospital of Sichuan University

    Chengdu, Sichuan, 610041, China

Conditions

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