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New mouthwash ingredient takes on dental germs in tiny trial

NCT ID NCT03384537

Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early study compares a mouthwash containing tropolone to the standard chlorhexidine 0.2% mouthwash for reducing bacteria that cause cavities. Thirty healthy adults aged 18–45 will stop their usual oral hygiene for a few days, then use one of the mouthwashes. Researchers will measure bacterial counts to see if tropolone works as well as chlorhexidine.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
tropolone-containing mouthwash
What this could lead to
If it works, this could point toward a gentler alternative to chlorhexidine for controlling dental bacteria.
What could go wrong
This is a very small early-phase study with only 30 people, so results may not apply widely. It also does not test long-term safety or effectiveness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2024

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients should be between 18- 45 years of age. 2. All the volunteers participated in this study will be healthy looking with free medical history. 3. The volunteers will be asked to suspend their usual oral hygiene practice from two to four days before experiment studying. Exclusion Criteria: 1. Patients with a compromised medical condition. 2. Volunteers that receive any antimicrobial agent during at least two weeks prior to study. 3. Volunteer with fixed, removable prosthesis or orthodontics appliance. 4. Volunteers with DMF above six will be excluded.

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Conditions

The condition(s) this trial relates to.

Stomatognathic Diseases dental caries prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental diseases

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Cairo University

    RECRUITING

    Cairo, Egypt

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