New hope for Hard-to-Treat lung cancer: targeted immunotherapy combo tested

NCT ID NCT06008093

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 24, 2026 · Updated 31 times

Summary

This study tests whether a combination of two immunotherapy drugs (durvalumab and tremelimumab) plus chemotherapy works better than the standard immunotherapy (pembrolizumab) plus chemotherapy for people with advanced non-small cell lung cancer that has specific gene mutations (STK11, KEAP1, or KRAS). About 100 participants with stage IV disease who have not had prior treatment will be enrolled. The goal is to see which combination helps delay cancer growth and improve survival.

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Contacts and locations

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Locations

Research Site

Beverly Hills, California, 90211, United States
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La Jolla, California, 92093, United States
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Los Alamitos, California, 90720, United States
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Los Angeles, California, 90034, United States
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Santa Monica, California, 90404, United States
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Washington D.C., District of Columbia, 20007, United States
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Fort Lauderdale, Florida, 33308, United States
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Jupiter, Florida, 33458, United States
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Ocala, Florida, 34474, United States
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Orlando, Florida, 32804, United States
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St. Petersburg, Florida, 33705, United States
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Atlanta, Georgia, 30318, United States
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Atlanta, Georgia, 30322, United States
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Honolulu, Hawaii, 96813, United States
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Carterville, Illinois, 62918, United States
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Urbana, Illinois, 61801, United States
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Bethesda, Maryland, 20817, United States
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Jamaica Plain, Massachusetts, 02130, United States
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Saint Paul, Minnesota, 55101, United States
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Kansas City, Missouri, 64132, United States
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St Louis, Missouri, 63128, United States
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Billings, Montana, 59102, United States
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Grand Island, Nebraska, 68803, United States
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Lincoln, Nebraska, 68506, United States
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Albany, New York, 12206, United States
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East Syracuse, New York, 13057, United States
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New York, New York, 10032, United States
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Shirley, New York, 11967, United States
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Stony Brook, New York, 11790, United States
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Syracuse, New York, 13210, United States
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The Bronx, New York, 10461, United States
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Cleveland, Ohio, 44111, United States
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Cleveland, Ohio, 44124, United States
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Cleveland, Ohio, 44195, United States
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Columbus, Ohio, 43210, United States
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Dayton, Ohio, 45459, United States
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Norman, Oklahoma, 73072, United States
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Pittsburgh, Pennsylvania, 15212, United States
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Sioux Falls, South Dakota, 57105, United States
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Memphis, Tennessee, 38120, United States
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Dallas, Texas, 75246, United States
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Denton, Texas, 76210, United States
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Houston, Texas, 77030, United States
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Houston, Texas, 77090, United States
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Kingwood, Texas, 77339, United States
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Fairfax, Virginia, 22031, United States
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Richmond, Virginia, 23298, United States

Conditions

Explore the condition pages connected to this study.

CARCINOMA, NON-SMALL-CELL LUNG