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Can a simple injection after knee surgery cut opioid use?

NCT ID NCT06955923

Symptom relief Sponsor: David Grant U.S. Air Force Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether giving a lidocaine injection into specific muscles right after knee replacement surgery could lower pain and the need for opioid painkillers. Eleven adults aged 45 and older who had knee surgery took part. Some received the real injection, while others got a sham (fake) injection. Researchers measured pain scores and opioid use over six weeks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
lidocaine
What this could lead to
If it works, this could offer a simple way to manage pain after knee surgery and reduce reliance on opioids.
What could go wrong
This is a very small pilot study with only 11 participants, so results may not be reliable or apply to everyone. The effect may be minimal or no better than a sham injection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

11 people

The number who actually took part.

Started

May 2025

Finished

Aug 2025

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 45 years or older * Planned to undergo primary total knee arthroplasty * Able to speak, read, and understand English * Willing to complete a study questionnaires * Willing to bring in their medications to be counted * DoD beneficiaries * No allergy to lidocaine * Not fearful of needles. Exclusion Criteria: * Chronic opioid users (daily use of prescribed opioids for at least 90 days) * Diagnosed with Fibromyalgia * Non-English speaking * Unable to read English * Unable to understand English * Pregnant * Allergy to lidocaine * Not willing to complete study questionnaires * Not willing to bring in their medications to be counted * Not a DoD beneficiary * Fearful of needles

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Conditions

The condition(s) this trial relates to.

myofascial pain syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Trigger point pain, myofascial

Contacts and locations

Locations

  • David Grant Medical Center

    Fairfield, California, 94535, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.