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Genome-First approach could end the diagnostic odyssey for kids with rare diseases

NCT ID NCT06935019

First seen Apr 30, 2026 · Last updated May 24, 2026 · Updated 4 times

Summary

This study compares doing comprehensive genome sequencing right away versus waiting for a genetics specialist and standard tests in 200 children with suspected rare genetic diseases. The goal is to see if the genome-first approach leads to faster and more accurate diagnoses. Participants will provide blood samples and complete questionnaires to help researchers understand the benefits, costs, and experiences of this new testing strategy.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Children's Hospital of Eastern Ontario

    Ottawa, Ontario, K1H 5B2, Canada

  • The Hospital for Sick Children

    Toronto, Ontario, M5G 0A4, Canada

Conditions

Explore the condition pages connected to this study.