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New breathing machine method aims to shield heart in lung failure patients

NCT ID NCT05629832

Disease control Sponsor: Beijing Chao Yang Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study tested a breathing machine strategy that uses lung pressure measurements to guide settings, aiming to protect the right side of the heart in patients with acute respiratory distress syndrome (ARDS). Forty adults on ventilators for less than 72 hours were included. The approach adjusts machine settings to keep lung pressure in a safe range, potentially reducing strain on the heart.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
mechanical ventilation strategy guided by transpulmonary pressure
What this could lead to
If this works, it could point toward a better way to use breathing machines to protect the heart in patients with severe lung injury.
What could go wrong
This is a small, early study with only 40 participants, so results may not apply to all patients. The approach is complex and requires special monitoring.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Jan 2023

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * duration of invasive mechanical ventilation less than 72 hours; * meet the diagnostic criteria of Berlin definition for ARDS; * age older than 18 Exclusion Criteria: * esophageal surgery or damage; * cardiac surgery; * severe bronchopleural fistula; * serious arrhythmia; pneumothorax; * tricuspid stenosis; * heparin allergy; * chronic pulmonary heart disease

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Conditions

The condition(s) this trial relates to.

acute cor pulmonale acute respiratory distress syndrome adult acute respiratory distress syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute cor pulmonale Acute respiratory distress syndrome

Contacts and locations

Locations

  • Beijing Chao-Yang Hospital

    Beijing, Beijing Municipality, 100020, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.