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Blood transfusion trends in trauma: what worked and what Didn't?

NCT ID NCT07603999

Knowledge-focused Sponsor: Mariah Arif Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked back at the medical records of 137 severely injured trauma patients who needed large blood transfusions between 2020 and 2025. Researchers analyzed how different transfusion strategies, such as balanced ratios and whole blood use, affected 30-day survival and other outcomes. The goal was to identify which practices may improve care for future trauma patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

137 people

The number who actually took part.

Started

Jan 2020

Finished

Dec 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult trauma patients (≥18 years) presenting directly to the trauma center were eligible for inclusion if they met at least one of the following criteria: 1. Injury Severity Score (ISS) ≥16, or 2. requirement for massive transfusion, defined as \>10 units of packed red blood cells (PRBC) within the first 24 hours.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Adult trauma patients (≥18 years) presenting directly to the trauma center were eligible for inclusion if they met at least one of the following criteria: 1. Injury Severity Score (ISS) ≥16, or 2. requirement for massive transfusion, defined as \>10 units of packed red blood cells (PRBC) within the first 24 hours. Exclusion Criteria: * Death on arrival, * Transfer from external institutions after initial resuscitation * Incomplete transfusion or outcome data * Significant pre-existing comorbidities (including advanced heart failure, end-stage renal disease, cirrhosis with portal hypertension, chronic oxygen dependence, or non-reversible anticoagulation therapy). * Patients with isolated minor injuries not requiring trauma team activation were also excluded.

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Conditions

The condition(s) this trial relates to.

injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Blood transfusion Mortality Transfusion Trauma coagulopathy

Contacts and locations

Locations

  • University of Florida Health Trauma One Center

    Gainesville, Florida, 32611, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.