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Heart failure drug showdown: which diuretic wins?

NCT ID NCT03296813

Disease control Sponsor: Duke University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared two common water pills (torsemide vs furosemide) in nearly 3,000 adults hospitalized with heart failure. The goal was to see which drug better prevents death or the need for repeat hospitalizations over 12 months. Participants were randomly assigned to one of the two medications and followed by phone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

2,973 people

The number who actually took part.

Started

Jul 2018

Finished

Jul 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patient hospitalized (≥ 24 hours or over a change in calendar date) with worsening of chronic heart failure, or new diagnosis of heart failure AND meets one of the following criteria: 1. Has a left ventricular ejection fraction (EF) ≤40% within 24 months prior to and including index hospitalization by any method (with most recent value used to determine eligibility) 2. Has an elevated natriuretic peptide level (either NT-pro-B-type natriuretic peptide or B-type natriuretic peptide) during index hospitalization as measured by local laboratory (with most recent value used to determine eligibility) 2. Plan for a daily outpatient oral loop diuretic regimen upon hospital discharge with anticipated need for long-term loop diuretic use 3. ≥ 18 years of age 4. Signed informed consent Exclusion Criteria: 1. End-stage renal disease requiring renal replacement therapy 2. Inability or unwillingness to comply with the study requirements 3. History of heart transplant or actively listed for heart transplant 4. Implanted left ventricular assist device or implant anticipated \<3 months 5. Pregnant or nursing women 6. Malignancy or other non-cardiac condition limiting life expectancy to \<12 months 7. Known hypersensitivity to furosemide, torsemide, or related agents

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Conditions

The condition(s) this trial relates to.

heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Heart failure

Contacts and locations

Locations

  • Abington Memorial Hospital

    Abington, Pennsylvania, 19001, United States

  • AtlantiCare Regional Medical Center

    Pomona, New Jersey, 08240, United States

  • Augusta University

    Augusta, Georgia, 30912, United States

  • Baylor University Medical Center

    Dallas, Texas, 75246, United States

  • Black Hills Cardiovascular Research

    Rapid City, South Dakota, 57701, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Columbia University Medical Center

    New York, New York, 10032, United States

  • Drexel University College of Medicine

    Philadelphia, Pennsylvania, 19102, United States

  • Duke (Duke Heart Center)

    Durham, North Carolina, 27710, United States

  • Emory Health Care

    Atlanta, Georgia, 30322, United States

  • Fox Valley Clinical Research Center

    Aurora, Illinois, 60506, United States

  • Froedtert Hospital

    Milwaukee, Wisconsin, 53226, United States

  • Good Samaritan Hospital

    Ephrata, Pennsylvania, 17522, United States

  • Greenville Hospital System University Medical Center

    Greenville, South Carolina, 29605, United States

  • Henry Ford Hospital

    Detroit, Michigan, 48202, United States

  • Holy Cross Hospital

    Fort Lauderdale, Florida, 33308, United States

  • Indiana University Health Bloomington Hospital

    Bloomington, Indiana, 47402, United States

  • Indiana University Medical Center

    Indianapolis, Indiana, 46202, United States

  • Inova Health Care Services

    Falls Church, Virginia, 22042, United States

  • Intermountain Medical Center

    Murray, Utah, 84107, United States

  • Jefferson University Hospital

    Philadelphia, Pennsylvania, 19107, United States

  • Kaiser Permanente Medical Center

    San Francisco, California, 94115, United States

  • Lester E. Cox Health Systems

    Springfield, Missouri, 65807, United States

  • Loyola University Medical Center

    Maywood, Illinois, 60153, United States

  • Main Line Health System

    Wynnewood, Pennsylvania, 19096, United States

  • Methodist Medical Center of Illinois

    Peoria, Illinois, 61606, United States

  • Montefore Medical Center - Albert Einstein University Hospital

    The Bronx, New York, 10461, United States

  • Mount Sinai

    New York, New York, 10029-6574, United States

  • New Hanover Regional Medical Center

    Wilmington, North Carolina, 28401, United States

  • North Shore University Hospital

    Manhasset, New York, 11030, United States

  • Northwestern Memorial Hospital

    Chicago, Illinois, 60611, United States

  • Novant Health Matthews Medical Center

    Matthews, North Carolina, 28240, United States

  • Oschner Clinic

    New Orleans, Louisiana, 70121, United States

  • Presbyterian/Brooklyn Methodist Hospital

    Brooklyn, New York, 11215, United States

  • Queens Medical Center

    Honolulu, Hawaii, 96813, United States

  • Russel Medical Center

    Alexander City, Alabama, 35010, United States

  • Saint Francis Hospital and Medical Center

    Hartford, Connecticut, 06105, United States

  • Saint Joseph Mercy Health System / Michigan Heart

    Ypsilanti, Michigan, 48197, United States

  • Sentara Norfolk General Hospital

    Norfolk, Virginia, 23507, United States

  • Shady Grove Medical Center

    Rockville, Maryland, 20850, United States

  • Stony Brook University Hospital

    Stony Brook, New York, 11794, United States

  • The Heart Center, PC

    Huntsville, Alabama, 35801, United States

  • University Hospitals Case Medical Center

    Cleveland, Ohio, 44106, United States

  • University Medical Center

    New Orleans, Louisiana, 70112, United States

  • University of Arizona

    Tucson, Arizona, 85724, United States

  • University of Chicago

    Chicago, Illinois, 60637, United States

  • University of Florida - Gainesville

    Gainesville, Florida, 32610, United States

  • University of Iowa Hospitals and Clinics

    Iowa City, Iowa, 52242, United States

  • University of Michigan Medical Center

    Ann Arbor, Michigan, 48109, United States

  • University of Minnesota

    Minneapolis, Minnesota, 55455, United States

  • University of Mississippi Medical Center

    Jackson, Mississippi, 29216, United States

  • University of North Carolina School of Medicine

    Chapel Hill, North Carolina, 27514, United States

  • University of Utah Hospitals and Clinics

    Salt Lake City, Utah, 84132, United States

  • V.A. Greater Los Angeles Healthcare System

    Los Angeles, California, 90073, United States

  • VA Medical Center/University of Maryland

    Baltimore, Maryland, 21201, United States

  • Virginia Commonwealth University Health

    Richmond, Virginia, 23298, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • Weill Cornell Medical College

    New York, New York, 10021, United States

  • West Haven VA Medical Center

    West Haven, Connecticut, 06516, United States

  • Yale

    New Haven, Connecticut, 06511, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.