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Zapping the brain while exercising shoulder: new hope for pain relief?

NCT ID NCT05951933

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study aimed to see if adding a mild electrical current to the brain (transcranial stimulation) during shoulder strengthening exercises helps people with subacromial pain syndrome more than exercise alone. Participants would have done 8 weeks of shoulder exercises while wearing a helmet that delivered either real or fake stimulation. However, the trial was withdrawn before any participants were enrolled, so no data was collected.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial electrical stimulation (a-TES)
What this could lead to
If it worked, this could point toward a way to boost the effects of physical therapy for shoulder pain using mild brain stimulation.
What could go wrong
The trial was withdrawn before enrolling anyone, so no results exist. Even if run, it was a small early study and the added benefit of brain stimulation may be minimal or none.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Expected to start

Jan 2023

An estimate. Start dates often move.

Expected to finish

Feb 2025

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Subjects will be evaluated during a first consultation by a physiotherapist with experience in shoulder musculoskeletal pathology, following the algorithm for the diagnosis of shoulder problems, recommended by the British Elbow \& Shoulder Society with the aim of detecting possible "flags red" and as a guide to rule out other shoulder pathologies that do not fit into the SDS. However, other tests will be added to ensure diagnostic accuracy, and these are described below. Inclusion Criteria: 1. Age between 18 and 65 years. 2. Duration of pain greater than or equal to 3 months. 3. Presence of 3 or more of the following positive clinical tests: * painful arc * External rotation test against isometric resistance * Neer's test * Jobe test or empty can test * Hawkins-Kennedy test Exclusion Criteria: 1. Previous shoulder or neck surgery. 2. History of shoulder fracture or dislocation. 3. Medical diagnosis of shoulder osteoarthritis. 4. Adhesive capsulitis 5. Cervicobrachialgia or reproducible shoulder pain with neck movements. 6. Clinical signs of total tear of the rotator cuff. 7. Corticosteroid injection in the previous 6 weeks. 8. Inflammatory disease, autoimmune or rheumatic, systemic (arthritis, lupus, myopathies). 9. Cognitive or behavioral problems that make it impossible to understand and follow the intervention (score less than 24 on the Mini-Mental State Examination Score) (73). 10. Any neurological or neoplastic disease. 11. Also those who present contraindications for transcranial electrical stimulation. For this, the recommendations of the checklist of Thair et al. which includes: * personal and family history of epilepsy * metal implants in the head * implanted medication pump * pacemaker * recurring headaches * skin diseases of the scalp (psoriasis, eczema) * head injuries * serious head surgeries * pregnancy * heart diseases * medications (psychotropics or antihistamines).

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of Valencia

    Valencia, Valencia, 46010, Spain

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