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Small study aims to perfect bleeding drug dose for joint replacements

NCT ID NCT05075200

Knowledge-focused Sponsor: Sunnybrook Health Sciences Centre Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed Phase 2 trial studied how the drug tranexamic acid (TXA) is processed in the body during hip or knee replacement surgery. 21 adults received a standard dose of TXA, and researchers measured drug levels in the blood to build a model for optimal dosing. The goal is to reduce blood loss and the need for transfusions after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
tranexamic acid
What this could lead to
If successful, this could lead to better dosing guidelines for tranexamic acid during joint replacement surgery, helping reduce blood loss and the need for transfusions.
What could go wrong
This was a small, early-phase study with only 21 participants, so results may not apply to all patients. The focus was on drug levels in the blood, not on direct patient outcomes like reduced transfusions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

21 people

The number who actually took part.

Started

Dec 2021

Finished

Oct 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria 1. Adults \> 18 years of age 2. Elective unilateral hip or knee joint replacement Exclusion Criteria 1. Contraindication to TXA (e.g., allergy, thrombophilia, tretinoin) 2. Advanced liver disease (\>2-fold rise in liver enzymes, as this may alter PK analysis) 3. Anti-coagulant use within the last 1-4 days prior (depends on anticoagulant, prior to the day of surgery)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Arthroplasty, replacement, hip Arthroplasty, replacement, knee

Contacts and locations

Locations

  • Sunnybrook Health Sciences Centre

    Toronto, Ontario, Canada

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