Nose surgery study: does drug dose tied to workload?
NCT ID NCT07450794
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study observes 90 adults undergoing nose surgery to see if a standard dose of tranexamic acid (a drug to reduce bleeding) affects how often anesthesiologists need to adjust pain medication. The goal is to understand if patient weight plays a role in anesthesiologist workload. No new treatments are being tested.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 90 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Mar 2026
An estimate. Start dates often move.
- Expected to finish
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Aug 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adult patients (18-70 years) undergoing elective septorhinoplasty under general anesthesia at a tertiary academic hospital. All patients receive a fixed 1 g intravenous dose of tranexamic acid as part of routine clinical practice, and intraoperative management includes a controlled hypotension strategy. Consecutive eligible patients with complete perioperative data are included in this prospective observational cohort.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥ 18 years * Elective septorhinoplasty under general anesthesia * Intraoperative administration of fixed 1 g intravenous tranexamic acid as part of routine practice * Controlled hypotension strategy applied intraoperatively * Surgery duration between 60-240 minutes * Complete intraoperative hemodynamic and drug titration records available Exclusion Criteria: * Emergency surgery * Additional major surgical procedure performed in the same session * Known coagulation disorder * Contraindication to tranexamic acid * History of thromboembolic disease * Chronic opioid use or opioid tolerance * Chronic pain syndrome * Regular use of sedatives, benzodiazepines, or CNS depressants * Severe cardiac, renal, or hepatic failure * Uncontrolled hypertension or significant arrhythmia * Preoperative hemoglobin \<10 g/dL * Major intraoperative complication * Incomplete or missing intraoperative data
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Istinye Üniversity
Istanbul, Merkez Mahallesi, 34250, Turkey (Türkiye)