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New drug combo shows promise for rare eye cancer

NCT ID NCT01979523

First seen Mar 16, 2026 · Last updated Jun 18, 2026 · Updated 12 times

Summary

This study tested two drug combinations in 42 people with advanced uveal melanoma, a rare eye cancer that has spread. The goal was to see if adding a second drug (GSK2141795) to trametinib could better slow cancer growth. Participants were randomly assigned to receive either trametinib alone or both drugs together. The study measured how long it took for the cancer to progress and monitored side effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Emory University Hospital/Winship Cancer Institute

    Atlanta, Georgia, 30322, United States

  • Institut Curie Paris

    Paris, 75005, France

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

    New York, New York, 10032, United States

  • The University of Liverpool

    Liverpool, L69 3GA, United Kingdom

  • UT MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Vanderbilt University/Ingram Cancer Center

    Nashville, Tennessee, 37232, United States

Conditions

The condition(s) this trial relates to.

uveal melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.