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Could an allergy drug boost lung cancer treatment? new trial investigates.

NCT ID NCT07358689

First seen Feb 01, 2026 · Last updated Jun 03, 2026 · Updated 27 times

Summary

This phase 2 trial tests whether adding an allergy medicine (diphenhydramine) to standard immunotherapy (toripalimab) and chemotherapy helps shrink lung tumors before surgery and prevents cancer from coming back after surgery. About 120 adults with stage IIA-IIIB non-small cell lung cancer will be randomly assigned to receive either the three-drug combo or just toripalimab plus chemo. The main goal is to see if the allergy drug leads to a complete disappearance of cancer cells in the removed tumor tissue.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Tianjin Medical University Cancer Institute & Hospital

    Tianjin, China

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.