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Menthol gel may keep runners cool – no ice needed

NCT ID NCT07482046

Symptom relief Sponsor: Taisho Pharmaceutical Indonesia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a gel containing 4% menthol, applied to the neck, arms, and legs, helps recreational runners feel cooler and perform better in hot conditions. Thirty-seven healthy adults aged 18 to 45 completed two runs, once with the menthol gel and once with a placebo. Researchers measured thermal sensation, body temperature, heart rate, and perceived exertion to see if the menthol gel made a difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Menthol 4% gel
What this could lead to
If it works, this could offer a simple, drug-free way to help runners feel cooler and perform better in hot conditions.
What could go wrong
This is a small, completed trial with only 37 participants. The effect may be limited to feeling cooler rather than actually lowering body temperature, and results may not apply to all athletes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

37 people

The number who actually took part.

Started

May 2023

Finished

Dec 2023

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults, 18 - 45 years old * Have a personal best 10-kilometer run time of under one hour (which will be confirmed during the screening of prospective Subjects through history taking) in the last 6 months. * Doing running training at least 3 times/week for the past 1 year * Have a level of heart-lung endurance or VO2max that is at least included in the average criteria (known through examination: Bleep test) * Meets Subject screening criteria by answering "No" to all questions on the Physical Activity Readiness Questionnaire (PAR-Q) questionnaire. * Have normal resting ECG and normal GDS results on screening of prospective Subjects. * At the time of the study, the body temperature was within the normal range Exclusion Criteria: * Pregnant and/or breastfeeding women * Have had a musculoskeletal injury in the last three months and still have symptoms or complaints * Are experiencing acute infectious disorders, such as gastrointestinal, respiratory infections * During treatment for chronic diseases (e.g. high blood pressure or hypertension, diabetes or diabetes mellitus, heart disease) * Have a history of hypersensitivity or allergy to menthol or skin-applied products (especially gel-based products) * Has a history of cold allergy * Have a positive COVID-19 test result at the time of screening.

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Conditions

The condition(s) this trial relates to.

Heat Stress Disorders Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Athletic performance Heat stress

Contacts and locations

Locations

  • Eminence Elite Clinic - Elite Club

    Jakarta, DKI Jakarta, 12940, Indonesia

More trials for these conditions

Other studies related to the condition(s) this trial covers.