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CBD oil for aching knees? new study seeks answers

NCT ID NCT07638189

Symptom relief Sponsor: University of Tennessee Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tests whether a topical CBD oil can reduce pain in people with knee osteoarthritis. Thirty participants will apply either CBD in castor oil or plain castor oil to their knees twice daily for 30 days, then switch treatments. Researchers will track pain scores and sleep quality to see if CBD offers relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cannabidiol (CBD) dissolved in castor oil
What this could lead to
If it works, this could point toward a new, natural option for managing knee osteoarthritis pain without the side effects of current medicines.
What could go wrong
This is a small pilot study with only 30 people, so results may not apply to everyone. CBD's pain-relieving effects are still unproven, and the placebo effect could be strong.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Knee OA (grade 2-3 as measured by the Kellgren-Lawrence Classification) 2. OA knee pain on the Visual Analog Pain Scale \> 4 in either knee 3. Receiving treatment at one of the eight Campbell Clinic Orthopaedics locations Exclusion Criteria: 1. Other forms of arthritis such as psoriatic arthritis or rheumatoid arthritis due to different sources of inflammation in these conditions 2. Allergies to CBD or Castor Oil 3. Current opioid use 4. BMI of over 40 5. Those who cannot walk without an assistance device (e.g., walker) 6. Those who are currently on knee injections (i.e. cortisol or hyaluronic acid gel) for knee pain 7. Patients scheduled for a knee replacement in the next 3-6 months 8. Active cannabis or CBD use 9. Alcohol consumption \> 21 alcoholic drinks each week 10. Active pregnancy, nursing, or actively planning a pregnancy 11. Active chronic liver or renal disease 12. Active depression/suicidality 13. Medications that interact with CBD in the liver that cannot be discontinued 14. Discretion of the Multiple Principal Investigators for concerns regarding noncompliance with the study intervention.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Tennessee Health Science Center

    Memphis, Tennessee, 38163, United States

More trials for these conditions

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