Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Could a common painkiller gel soothe your itch?

NCT ID NCT03997851

Symptom relief Sponsor: University of Miami Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This small study tested whether a gel made from acetaminophen (the active ingredient in Tylenol) can relieve itching. Seventeen healthy volunteers received different strengths of the gel or a placebo on their skin, then had itch triggered by two different methods. The goal was to see if the gel reduced itch intensity compared to placebo.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
acetaminophen gel
What this could lead to
If it works, this could point toward a new over-the-counter option for itch relief, especially for types of itch that antihistamines don't help.
What could go wrong
This is a very small, early proof-of-concept study in only 17 healthy people, not patients with chronic itch. The results may not apply to real-world itching conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

17 people

The number who actually took part.

Started

Jul 2019

Finished

Mar 2020

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Healthy subjects must be between 18 and 50 years of age. 2. Must be in general good health with no disease or physical conditions that would impair evaluation of itch and pain perception. 3. No history of chronic itch or pain. 4. Must abstain from the use of any systemic or topical anti-histamine, steroid, or pain relief medications from the week prior to the study till the completion of the study. 5. Must abstain from the use of moisturizers on the arms 24 hours before study visits. Exclusion Criteria: 1. Individuals under 18 or over 50 years of age. 2. Inability to complete the required measures. 3. The presence of an itchy skin disease. 4. Diagnosis of diseased that would affect itch or pain perception (e.g. neuropathies). 5. Currently enrolled in any investigational study in which the subject is receiving any type of drug, biological, or non-drug therapy. 6. Use of oral, topical analgesics, or other medications known to interfere with itch or pain perception in the week prior to the study and throughout the study (e.g. antihistamines, anesthetics, opioids, neuroleptics, etc.). 7. Use of emollients on the arms a week prior to the study and throughout the study. 8. Known allergies to acetaminophen and cowhage. 9. Pregnant women. (Women of child bearing potential will undergo an hCG pregnancy test). 10. Currently incarcerated.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Pruritus are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

Pruritus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pruritus

Contacts and locations

Locations

  • University of Miami

    Miami, Florida, 33136, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.