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Can a different opioid reduce Post-C-Section itching?

NCT ID NCT02277678

Symptom relief Sponsor: KK Women's and Children's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This trial compares two epidural opioids—oxycodone and morphine—for pain relief after an elective cesarean section. The main focus is on how well each controls pain and how often they cause itching, a common side effect. Secondary goals include checking for nausea, vomiting, sedation, and breathing problems. About 100 women aged 21–50 who are having a planned C-section under combined spinal-epidural anesthesia will participate.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Epidural oxycodone compared with epidural morphine
What this could lead to
If oxycodone works as well as morphine for post-cesarean pain with less itching, it could become a preferred option for new mothers.
What could go wrong
This is a single trial with 100 participants, so results may not apply broadly. Both drugs can cause side effects like nausea, vomiting, or drowsiness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

100 people

The number who actually took part.

Start date

Aug 2013

Finished

Dec 2014

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 50 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status 1-2, * aged between 21 to 50 years undergoing a term elective caesarean section and * had consented for combined spinal-epidural (CSE) anaesthesia Exclusion Criteria: * concurrent opioid therapy, * contraindications to CSE anaesthesia or any of the study medications, * a history of pre-existing nausea and vomiting, * failure to identify intrathecal space at time of anaesthesia, * inadvertent dural puncture with the epidural needle and * conversion of regional anaesthesia to general anaesthesia

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Conditions

The condition(s) this trial relates to.

Pruritus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pruritus

Contacts and locations

Locations

  • KK Women's and Children's Hospital

    Singapore, 229899, Singapore

More trials for these conditions

Other studies related to the condition(s) this trial covers.