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New tooth treatments battle ugly white spots without drilling

NCT ID NCT07086235

Disease control Sponsor: Nahda University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested two treatments for white spot lesions on teeth, which are common after braces. One uses a self-assembling peptide with fluoride to rebuild enamel, and the other uses a protective coating that releases minerals. Forty-four people with at least two white spots were treated, and the researchers measured color change and lesion depth. The goal is to find a better, less invasive way to improve tooth appearance.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
self-assembling peptide with fluoride (Curodont Repair Fluoride Plus) and tooth protective coating with surface pre-reacted glass (S-PRG Barrier Coat)
What this could lead to
If successful, this could offer a minimally invasive way to restore the natural appearance of teeth with white spots, improving patient satisfaction without drilling or anesthesia.
What could go wrong
This is a small, completed trial with only 44 participants, so results may not apply to everyone. The treatments are cosmetic and do not cure underlying decay or disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

44 people

The number who actually took part.

Started

Feb 2025

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 25 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- No systemic diseases. 2- He/ she has at least two teeth with white spot lesion due to orthodontic therapy. 3- Between the ages of 21 and 25 years of age. Exclusion criteria: 1. Presence of enamel hypoplasia or dental fluorosis. 2. Presence of tetracycline pigmentation. 3. Periodontal pocketing of 3 mm or greater. 4. Presencia de cavidades cariosas. 5. Allergy to fluoride. 6. Subjects who have evidence of reduced salivary flow or significant tooth wear.

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Conditions

The condition(s) this trial relates to.

enamel caries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

White spot lesions

Contacts and locations

Locations

  • Nahda University

    Banī Suwayf, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.