New toothpaste promises brighter smiles without fluoride
NCT ID NCT07214038
First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 2 times
Summary
This study compares a non-fluoride toothpaste containing nano-hydroxyapatite and a special silica abrasive to a standard fluoride toothpaste for whitening teeth. 120 adults will brush with one of the two toothpastes for 2 weeks. Researchers will measure stain reduction using a standard index to see which toothpaste works better.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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120 people
The number who actually took part.
- Started
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Sep 2025
- Finished
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Nov 2025
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Consent Demonstrates understanding of the study and willingness to participate as evidenced by voluntary written informed consent and has received a signed and dated copy of the informed consent form. 2\) Age Aged at least 18 years. 3\) Compliance Understands and is willing, able and likely to comply with all study procedures and restrictions. 4\) General Health Good general health with no clinically significant and relevant abnormalities of medical history or dental examination in the opinion of the investigator or dental assessor. 5\) Dental Details 1. Good oral health with 16 natural teeth including 11 of the 12 anterior teeth. 2. All facial surfaces gradable with no large restorations as judged by the investigator or dental assessor. Exclusion Criteria: Pregnancy Women who are known to be pregnant or who are intending to become pregnant over the duration of the study. 2\) Breast-feeding Women who are breast-feeding. 3\) Allergy/Intolerance Known or suspected intolerance or hypersensitivity to the study materials (or closely related compounds) or any of their stated ingredients. 4\) Clinical Study/Experimental Medication 1. Participation in another clinical study or receipt of an investigational drug within 30 days of the screening visit. 2. Previous participation in this study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Global Health Research Group
New Delhi, National Capital Territory of Delhi, 110048, India
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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