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New toothpaste promises brighter smiles without fluoride

NCT ID NCT07214038

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 2 times

Summary

This study compares a non-fluoride toothpaste containing nano-hydroxyapatite and a special silica abrasive to a standard fluoride toothpaste for whitening teeth. 120 adults will brush with one of the two toothpastes for 2 weeks. Researchers will measure stain reduction using a standard index to see which toothpaste works better.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

120 people

The number who actually took part.

Started

Sep 2025

Finished

Nov 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Consent Demonstrates understanding of the study and willingness to participate as evidenced by voluntary written informed consent and has received a signed and dated copy of the informed consent form. 2\) Age Aged at least 18 years. 3\) Compliance Understands and is willing, able and likely to comply with all study procedures and restrictions. 4\) General Health Good general health with no clinically significant and relevant abnormalities of medical history or dental examination in the opinion of the investigator or dental assessor. 5\) Dental Details 1. Good oral health with 16 natural teeth including 11 of the 12 anterior teeth. 2. All facial surfaces gradable with no large restorations as judged by the investigator or dental assessor. Exclusion Criteria: Pregnancy Women who are known to be pregnant or who are intending to become pregnant over the duration of the study. 2\) Breast-feeding Women who are breast-feeding. 3\) Allergy/Intolerance Known or suspected intolerance or hypersensitivity to the study materials (or closely related compounds) or any of their stated ingredients. 4\) Clinical Study/Experimental Medication 1. Participation in another clinical study or receipt of an investigational drug within 30 days of the screening visit. 2. Previous participation in this study.

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Conditions

The condition(s) this trial relates to.

Tooth Discoloration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Global Health Research Group

    New Delhi, National Capital Territory of Delhi, 110048, India

More trials for these conditions

Other studies related to the condition(s) this trial covers.