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New monthly shot could tame stubborn high blood pressure

NCT ID NCT06864104

Disease control Sponsor: Kardigan, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a monthly injection called tonlamarsen in 206 adults whose blood pressure stays high even after taking two or more daily medications. The goal was to see if the shot can safely lower blood pressure and reduce a protein linked to hypertension. Results will show whether this approach might help people who need extra control.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Tonlamarsen (a monthly injection)
What this could lead to
If it works, this could offer a new monthly injection option for people whose blood pressure remains high despite taking multiple daily pills.
What could go wrong
This is a Phase 2 trial with only 206 participants, so results may not apply to everyone. The drug may not lower blood pressure enough or could cause side effects like high potassium levels.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

206 people

The number who actually took part.

Started

Apr 2025

Finished

Mar 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Key Inclusion Criteria: * Age 18 to 80, body weight ≥ 50 kg * Has uncontrolled hypertension while receiving between 2 and 5 antihypertensive medications prescribed for hypertension * Has mean office seated systolic blood pressure \> 135 to ≤ 170 mmHg Key Exclusion Criteria: * Has known history of secondary hypertension * Has documented history of poor adherence to antihypertensive medication * Has unstable/underlying known cardiovascular disease * Has abnormal thyroid function with clinical significance

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Conditions

The condition(s) this trial relates to.

hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypertension

Contacts and locations

Locations

  • Achieve Clinical Research, LLC

    Birmingham, Alabama, 35216, United States

  • ActivMed Practices & Research, LLC

    Methuen, Massachusetts, 01844, United States

  • Advanced Medical Trials, LLC

    Georgetown, Texas, 78628, United States

  • Agile Clinical Research Trials, LLC

    Atlanta, Georgia, 30328, United States

  • American Institute of Research

    Los Angeles, California, 90017, United States

  • CHEAR Center LLC

    The Bronx, New York, 10455, United States

  • Cardiology and Medicine Clinic

    Little Rock, Arkansas, 72204, United States

  • Central Texas Clinical Research

    Austin, Texas, 78705, United States

  • Clinical Investigation Specialists, Inc.

    Gurnee, Illinois, 60031, United States

  • Clinical Trials Research

    Lincoln, California, 95648, United States

  • Clinical Trials of South Carolina

    Moncks Corner, South Carolina, 29461, United States

  • Del Sol Research Management, LLC

    Tucson, Arizona, 85715, United States

  • DelRicht Clinical Research - New Orleans

    New Orleans, Louisiana, 70115, United States

  • Eagle Clinical Research

    Chicago, Illinois, 60621, United States

  • Elite Clinical Studies

    Phoenix, Arizona, 85018, United States

  • Health Concepts

    Rapid City, South Dakota, 57702, United States

  • Holston Medical Group

    Kingsport, Tennessee, 37660, United States

  • Homestead Associates in Research, Inc.

    Homestead, Florida, 33033, United States

  • IMA Clinical Research

    Monroe, Louisiana, 71201, United States

  • IMA Clinical Research

    Lenoir, North Carolina, 28645, United States

  • Jacksonville Center for Clinical Research

    Jacksonville, Florida, 32216, United States

  • Juno Research, LLC

    Houston, Texas, 77040, United States

  • Koch Family Medicine Clinical Research

    Morton, Illinois, 61550, United States

  • Manassas Clinical Research Center

    Manassas, Virginia, 20110, United States

  • North Coast Cardiology

    Encinitas, California, 92024, United States

  • North Hills Medical Research

    North Richland Hills, Texas, 76180, United States

  • Oakland Medical Research Center

    Troy, Michigan, 48085, United States

  • Olive Branch Family Medical Center

    Olive Branch, Mississippi, 38654, United States

  • Orange County Research Center

    Lake Forest, California, 92630, United States

  • Pinnacle Research Group

    Anniston, Alabama, 36207, United States

  • Progressive Medical Research

    Port Orange, Florida, 32127, United States

  • Radiance Clinical Research

    Lampasas, Texas, 76550, United States

  • Richmond University Medical Center

    Staten Island, New York, 10310, United States

  • Sun Research Institute

    San Antonio, Texas, 78215, United States

  • Suncoast Clinical Research, Inc.

    New Port Richey, Florida, 34652, United States

  • Synergy Groups Medical, LLC

    Missouri City, Texas, 77459, United States

  • Tandem Clinical Research GI, LLC

    Marrero, Louisiana, 70072, United States

  • Velocity Clinical Reseach

    Savannah, Georgia, 31406, United States

  • York Clinical Research LLC

    Norfolk, Virginia, 23504, United States

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