Experimental chest injection aims to stop cancer fluid buildup

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age between 18 and 75 years (inclusive) at the time of signing the informed consent form. 2. Histologically or cytologically confirmed malignant pleural effusion, with the primary tumor diagnosed as non-small cell lung cancer (NSCLC). 3. Eastern Cooperative Oncology Group (ECOG) performance status of 0-2, with an expected survival of at least 3 months. 4. Presence of dyspnea symptoms. 5. No prior local thoracic treatment within 1 month before enrollment, including intrapleural drug administration or thoracic radiotherapy (diagnostic thoracentesis is permitted). 6. Except for the subject's current stable systemic anti-tumor therapy, any other ongoing tumor-related treatments must be suspended or discontinued after evaluation by the investigator to ensure they do not interfere with the assessment of PTS treatment. 7. Fully understands the study objectives and procedures, agrees to participate in the study, and provides written informed consent. Exclusion Criteria: 1. History of allergy or hypersensitivity to PTS or any of its excipients. 2. Presence of uncontrolled intrapleural infection or severe loculated pleural effusion that is difficult to manage. 3. Participation in another interventional clinical study within 3 months prior to enrollment (diagnostic studies are excluded). 4. Severe organ dysfunction, including but not limited to coagulation disorders, congestive heart failure, malignant arrhythmias, coronary artery disease requiring long-term medication, valvular heart disease, myocardial infarction, or refractory hypertension; severe cardiac, hepatic, or renal insufficiency, or active bleeding or thrombotic risk. 5. Presence of uncontrolled infectious wounds. 6. Pregnant or breastfeeding women. 7. Any other condition that, in the investigator's judgment, makes the subject unsuitable for participation in this study. 8. Criteria for withdrawal from the study.