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Zapping the Brain's reward center to fight anhedonia

NCT ID NCT05468853

Symptom relief Sponsor: Florida State University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a type of brain stimulation called TMS could reduce anhedonia, or loss of interest or pleasure. 72 adults with elevated anhedonia received TMS targeting the brain's reward circuit. Researchers measured changes in self-reported anhedonia and brain activity using EEG and fMRI.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial magnetic stimulation (TMS)
What this could lead to
If it works, this could point toward a non-drug treatment for anhedonia, a common symptom in depression and other conditions.
What could go wrong
This is a small, early-stage study with no placebo group, so results may not be reliable or apply to everyone. TMS can cause mild side effects like headache or scalp discomfort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

72 people

The number who actually took part.

Started

Jun 2022

Finished

Sep 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Right-handed * Native English speaker or fluent by the age of 6 * Elevated self-reported anhedonia Exclusion Criteria: * Left-handed * Metal in head * Brain tumor, stroke, aneurysm, multiple sclerosis * Active substance use disorder in last 3 months * Dementia or other cognitive disorder making unable to engage in treatment * History or diagnosis of schizophrenia, schizoaffective disorder, delusional disorder, or other psychiatic illness that precludes safe participation in trial * Suicidal risk that precludes safe participation * obsessive-compulsive disorder * Inability to stop taking any mediation that significant lowers the seizure threshold (e.g. tricyclic antidepressants, clozapine, etc.) * Severe traumatic brain injury * Non-English speaker

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Transcranial magnetic stimulation

Contacts and locations

Locations

  • FSU MRI Facility

    Tallahassee, Florida, 32306, United States

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