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Brain zaps for space brains: TMS study aims to sharpen astronaut performance

NCT ID NCT04123496

Knowledge-focused Sponsor: Medical University of South Carolina Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a short, non-invasive brain stimulation technique called TMS could improve thinking skills like attention and memory, and help people bounce back from stress. Thirty-eight healthy adults received brief TMS sessions targeting a key brain area. The goal was to find the best dose for future use in astronauts, but the results are still being analyzed.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Repetitive Transcranial Magnetic Stimulation (rTMS)
What this could lead to
If it works, this could point toward a non-drug method to sharpen thinking and handle stress better, potentially for astronauts or others in high-pressure jobs.
What could go wrong
This is a small, early study in healthy adults, not astronauts. Results may not apply to real space missions, and benefits might be short-lived or not noticeable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

38 people

The number who actually took part.

Started

Nov 2019

Finished

Oct 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

22 to 55 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. No history of mental or physical illness 2. No implanted metal in the body 3. College graduates (Associates degree or higher) 4. Negative urine pregnancy test, if female subject of childbearing potential 5. Able to read and understand questionnaires and informed consent Exclusion Criteria: 1. Any current psychiatric diagnosis or current Clinical Global Impression ratings of psychiatric illness \> 1 2. Current physical illness 3. History of CNS disease, concussion, overnight hospitalization, tumors, seizures, meningitis, encephalitis, abnormal CT/MRI of the brain 4. Moderate to severe traumatic brain injury (TBI) 5. History of a continuing significant laboratory finding 6. Frequent or severe headaches 7. Any history of psychotropic medication prior to study enrollment 8. Females of childbearing potential who are pregnant (by urine HCG), nursing, or who are not using a reliable form of birth control. 9. active participation or plan for enrollment in another evidence-based clinical trial affecting psychosocial function 10. repeated abuse or dependence upon drugs (excluding nicotine and caffeine) 11. implanted devices/ferrous metal of any kind

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Conditions

The condition(s) this trial relates to.

cognitive disorder Fractures, Stress Stress, Psychological

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cognition Stress reaction

Contacts and locations

Locations

  • Medical University of South Carolina

    Charleston, South Carolina, 29401-5799, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.