Brain zaps tuned to your wiring: a new hope for depression?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 一、Inclusion criteria for the depressed group: 1. Aged 18-30 years; 2. Recent feelings of low mood and presence of depressive symptoms; 3. Physically healthy, with no history of neurological disorders; 4. No participation in other neuromodulation experiments within the past month; 5. Normal hearing and normal (or corrected-to-normal) vision; 6. PHQ-9 score \> 5 and BDI-II score \> 13; 7. Avoidance of staying up late, alcohol consumption, and excessive caffeine intake prior to the experiment; 8. Able and willing to cooperate with the completion of scale assessments. 二、Inclusion criteria for healthy participants: (1) Aged 18-30 years; (2) No significant symptoms of depression and no history of neuropsychiatric disorders; (3) Physically healthy with no history of neurological disorders; (4) No participation in other neuromodulation experiments within the past month; (5) Normal hearing and normal (or corrected-to-normal) vision; (6) PHQ-9 score \< 5 and BDI-II score \< 13; (7) Avoidance of staying up late, alcohol consumption, and excessive caffeine intake prior to the experiment; (8) Able and willing to cooperate with the completion of scale assessments. Exclusion Criteria: 1. History of head trauma (including neurosurgery), stroke, elevated intracranial pressure, or other brain-related disorders; 2. History of epileptic seizures or family history of epilepsy; 3. Receipt of TMS or other neuromodulation stimulation within the past month; 4. Presence of intracranial or internal metallic foreign bodies, electrodes made of silver or gold, or metal prostheses; 5. Presence of devices potentially affected by TMS, such as pacemakers, drug pumps, cochlear implants, or implanted brain stimulators; 6. Severe or recent cardiac, pulmonary, or hematopoietic system disorders, or other neurological diseases; 7. Clinically diagnosed moderate-to-severe depressive disorder; 8. Substance abuse, alcohol dependence, etc.; 9. Current active suicidal ideation or suicidal behavior; Refusal to sign the informed consent form.