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TMJ sufferers: could a simple injection stop the clicking?

NCT ID NCT06403046

Symptom relief Sponsor: Beni-Suef University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This completed trial tested two anti-inflammatory drugs, tenoxicam and meloxicam, injected into the jaw joint after a routine washout procedure. The goal was to reduce pain, clicking, and improve mouth opening in 30 adults with a specific type of TMJ disorder. The study compares which drug works better for symptom relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Tenoxicam and Meloxicam (anti-inflammatory drugs)
What this could lead to
If successful, this could point toward a simple injection-based treatment to ease TMJ pain and clicking without surgery.
What could go wrong
This is a small, early-phase trial with only 30 participants, so results may not apply to everyone. The treatment targets symptoms, not the underlying disc position.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

30 people

The number who actually took part.

Started

Jun 2024

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients of both sexes with an age range of 18-45 years. 2. Those patients with the radiographic interpretation of unilateral or bilateral (TMJ) anterior disc displacement with reduction with the clinical signs of pain, limitation of mouth opening, and TMJ clicking; Wilkes classification type II. Exclusion Criteria: 1. Clinical or radiographic signs of disc displacement without reduction, osteoarthritis, or articular bony changes. 2. Previous (TMJ) surgery, arthrocentesis, or occlusal splints. 3. Any systemic disease affecting the temporomandibular joint's anatomy, mechanical function, or outcome of the proposed treatment. 4. Those Patients with a history of allergic reactions to any components of the injectable solutions.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Temporomandibular joint disc displacement, with reduction

Contacts and locations

Locations

  • Beni-suef university

    Banī Suwayf, Egypt

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