Which antibiotic combo wins against h. pylori? a Head-to-Head test
NCT ID NCT07746934
First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time
Summary
This trial compares two 14-day antibiotic combinations for treating Helicobacter pylori, a common stomach bacteria that can cause ulcers and stomach cancer. One combination uses metronidazole, the other uses a similar drug called tinidazole. The study will see if tinidazole is just as effective at eradicating the infection, while also comparing side effects and tolerability.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Tinidazole-based bismuth quadruple therapy (tinidazole, esomeprazole, tetracycline, bismuth subcitrate) compared to metronidazole-based bismuth quadruple therapy
- What this could lead to
- If tinidazole works as well as metronidazole, doctors may have another effective option for treating H. pylori infections, potentially with fewer side effects.
- What could go wrong
- This is a head-to-head comparison, not a new drug discovery. The outcome depends on real-world effectiveness and tolerability, and results may not apply to all populations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 600 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jul 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults aged 18 years or older. * Confirmed Helicobacter pylori infection * Willing and able to provide written informed consent. Exclusion Criteria: * Pregnancy or breastfeeding. * Gastrointestinal malignancy. * Previous H. pylori eradication therapy. * Liver cirrhosis. * Stage IV or V chronic kidney disease. * Previous gastric surgery. * Known allergy to any study medication. * Use of antibiotics within the previous 4 weeks.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of Medicine and Pharmacy at Ho Chi Minh City
Ho Chi Minh City, Ho Chi Minh, 70000, Vietnam
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