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Eye drop gel shows promise for skin graft healing, but trial stalls

NCT ID NCT03579160

Disease control Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested whether applying 0.25% timolol gel (a beta-blocker eye drop used for glaucoma) to skin grafts could improve healing and appearance after skin cancer surgery. Researchers planned to enroll 82 patients but stopped early with only 10 participants. The goal was to see if the gel helps wounds heal faster and look better compared to standard Vaseline dressing.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
0.25% timolol gel
What this could lead to
If it works, this could offer a simple, low-cost way to improve healing and cosmetic outcomes for skin grafts after cancer surgery.
What could go wrong
The trial was terminated early with only 10 participants, so results are very limited. It is unclear if timolol gel is truly effective or safe for this use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

10 people

The number who actually took part.

Started

Jan 2019

Finished

Jan 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥18 years of age 2. Undergoing a procedure which results in the need of a FTSG 3. Willing to provide written informed consent Exclusion Criteria: 1. Age less than 18 years of age 2. Pregnant women 3. (Use of systemic drugs that can impede wound healing, such retinoids or immune-suppressive drugs) 4. Severe coagulation disorders 5. Severe, uncontrolled systemic comorbidities, such as diabetes, arthritis, etc. 6. Hypersensitivity to 0.25% timolol gel 7. Not willing to provide written informed consent

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Conditions

The condition(s) this trial relates to.

injury skin cancer Surgical Wound

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Full thickness skin graft healing Surgical wound Wound heal Wound of skin

Contacts and locations

Locations

  • Mohs and Dermatologic Surgery Center, Brigham and Women's Hospital

    Boston, Massachusetts, 02130, United States

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