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Experimental triple therapy takes on tough tumors

NCT ID NCT06760481

First seen Nov 01, 2025 · Last updated Jun 19, 2026 · Updated 32 times

Summary

This early-phase trial is testing a combination of two immunotherapy drugs (tiragolumab and atezolizumab) plus a special type of radiation (RadScopal) in 7 people with advanced solid tumors that have not responded to standard treatments. The main goal is to check safety and side effects. Researchers hope this mix might help the immune system fight cancer more effectively.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • The University of Texas M. D. Anderson Cancer Center

    Houston, Texas, 77030, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Tiragolumab, Atezolizumab, and RadScopal radiation

What this could lead to

If it works, this could point toward a new combination therapy for advanced cancers that have run out of standard options.

What could go wrong

This is a very early Phase I trial with only 7 participants, so it is primarily testing safety, not effectiveness. The combination may cause significant side effects or fail to shrink tumors.

Conditions

The condition(s) this trial relates to.

cancer metastatic malignant neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.