Heart drug combo pill tested for easier dosing
NCT ID NCT07444164
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed Phase 1 trial tested whether a single capsule containing 90 mg ticagrelor and 100 mg aspirin works the same in the body as taking the two drugs separately. Twenty-four healthy adults in Mexico participated. The study measured how much of each drug reached the bloodstream and how fast the body cleared them.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Ticagrelor and acetylsalicylic acid (aspirin) in a single capsule
- What this could lead to
- If successful, this could lead to a simpler, single-pill option for patients who need both ticagrelor and aspirin.
- What could go wrong
- This is an early-stage study in only 24 healthy people, so results may not predict how the drug works in patients or reveal all side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
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24 people
The number who actually took part.
- Started
-
Jan 2025
- Finished
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Feb 2025
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 55 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Subjects who have given informed consent in writting * Subjects of both genders aged between 18 and 55 years, mexicans, with no background of hypersensitivity or allergies to the drugs under study or related drugs. * Subjects with no background of using anticoagulants of any kind. * Subjects with no background of hepatitis B and/or C. * Vital signs within normal limits, according to international guidelines recorded during selection. * Electrocardiographic trace without evidence of conduction disorders, with RR, PR, QRS, and QT ranges and ST segment values within physiological limits. * Body mass index between 18.0 - 27.0 (kg/m2). * Negative drug abuse test for both men and women. * Negative pregnancy test for women. * All women who agree to participate in the study and who use some form of contraception barrier method such as male or female condoms, copper intrauterine devices (IUDs), or male or female sterilization. * No background of food allergies. * No background of medication use for 14 consecutive days or less than 9 half-lives of the last dose administered of the indicated medication prior to the start of the study. * Background of participation in clinical studies similar to this one within a period of 3 months prior to the study. * No presence of Hepatitis B surface antigens or antibodies against Hepatitis C, HIV, and VDRL core proteins. * No background of alcohol consumption during the study selection period. * No background of donating or losing 450 mL or more of blood within 60 days prior to the study. Exclusion Criteria: * Individuals with hypersensitivity to ticagrelor, acetylsalicylic acid, or any of their components. * Subjects with background of use of anticoagulants. * Subjects with background of hepatitis B and/or C. * Vital signs outside normal limits, according to international guidelines recorded during selection. * Electrocardiogram showing evidence of conduction disturbances, with RR, PR, QRS, and QT intervals and ST segment values within physiological limits. * Body mass index below 18.0 (kg/m2) or above 27.0 (kg/m2). * During the medical history process, the subject indicated background of abuse and dependence on alcohol, psychoactive substances, and chronic use of medications. * Positive drug abuse test for both men and women. * Positive pregnancy test for women. * Background of food allergies. * Background of participation in clinical studies similar to the present study within a period of less than 3 months prior to the study. * Presence of Hepatitis B surface antigens or antibodies against Hepatitis C, HIV, and VDRL core proteins. * Health assessment other than healthy, determined by the results of questioning, physical examination, laboratory tests: blood count, blood chemistry to assess liver and kidney function, fasting lipids and glucose, general urine test, and serology for hepatitis B and C, VDRL, HIV, and electrocardiogram. * In a subordinate relationship with the company or researcher.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centro de Estudios Científicos y Clínicos Pharma S.A. de C.V.
Xochitepec, Morelos, 627790, Mexico
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